cgs4144

Team Members: Richard Hou, Johnson Nguyen, Rayyan Shaikh

Data: Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain

Question: Does loss of Trem2 disrupt brain cell communication networks in a way that increases vulnerability to Alzheimer’s disease?

installed packges from requirements.txt provide SRP119064 folder in root

run id-to-geneName-script.py to get new tsv (expression_with_gene_names.tsv)

run expression-matrix-script.py to get summary of findings

summary of findings: Matrix size: 41249 genes × 483 samples Summary of per-gene median expression (log2 scale): count 41249.000000 mean 1.308183 std 1.315714 min 0.195652 25% 0.196322 50% 0.920552 75% 2.144825 max 7.519327 dtype: float64

run generate-plots.py to get plot