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N4BiasFieldCorrection bspline_fitting_distance in t1-linear pipeline (default ~600mm?) #1691

@jianfeixu95

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@jianfeixu95

Hi all,

I would like to discuss the configuration of the N4 bias field correction step in the t1-linear pipeline, specifically regarding the parameter:

n4biascorrection.inputs.bspline_fitting_distance = 600

n4biascorrection.inputs.bspline_fitting_distance = 600


According to the ANTs documentation https://github.com/ANTsX/ANTs/wiki/N4BiasFieldCorrection, the spline spacing (-b) parameter should typically be set within a certain range for human brain MRI:

“For human brain images, this should generally be somewhere between 100 and 200 mm.”

Additionally, in ANTsPy / ANTsR, the default spline spacing is around: https://antsx.github.io/ANTsR/reference/n4BiasFieldCorrection.html

“Default … is 200 mm per mesh element in each dimension.”

Would it be reasonable to modify this parameter ? (e.g., to 200 mm) for:

  • better computational efficiency
  • potentially improved bias correction fidelity

CHEERS~

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