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<!DOCTYPE HTML>
<!--
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<html>
<head>
<title>Qihuang Zhang | 张启煌</title>
<meta charset="utf-8" />
<meta name="viewport" content="width=device-width, initial-scale=1, user-scalable=no" />
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<!-- Header -->
<header id="header">
<div class="inner">
<a href="#" class="image avatar"><img src="images/Qihuang.jpg" alt="" /></a>
<h1><strong>Assistant Professor</strong><br />
<a href="https://www.mcgill.ca/epi-biostat-occh/qihuang-zhang">McGill University</a></h1>
</div>
</header>
<!-- Main -->
<div id="main">
<!-- One -->
<section id="one">
<header class="major">
<h2>
<img src="images/StatGill_Logo.png" alt="Lab Logo" style="height: 120px; vertical-align: middle; margin-right: 5px;">
Statistical Genomics and Intelligence Learning Laboratory
</h2>
</header>
<ul class="actions">
<li><a href="index.html" class="button">About Me</a></li>
<li><a href="Research.html" class="button">Our Lab</a></li>
<li><a href="Teach.html" class="button"> My Classroom</a></li>
<li><a href="files/QihuangZhang_CV_tex.pdf" class="button" target="_blank">My CV</a></li>
</ul>
</section>
<!-- Two -->
<section id="research">
<header class="major">
<h2>Research</h2>
</header>
<ul class="actions small">
<li><a href="#axis1" class="button small"><span class="icon solid fa-dna"></span> Axis 1</a></li>
<li><a href="#axis2" class="button small"><span class="icon solid fa-project-diagram"></span> Axis 2</a></li>
<li><a href="#axis3" class="button small"><span class="icon solid fa-heartbeat"></span> Axis 3</a></li>
</ul>
<p style="color: #cc5a36; line-height: 1.6; margin-bottom: 2em;">
<span style="font-weight: bold;">To prospective students:</span> I welcome applications for PhD and Postdoctoral positions related to Axis 1 and 2 of my research program. Interested candidates are encouraged to apply through the McGill Biostatistics or Quantitative Life Sciences programs.
I also host undergraduate students through specialized summer research programs. These opportunities typically involve collaborative group projects, offering hands-on experience in statistical genomics and computational methods.
</p>
<h3 id="axis1"><span class="icon solid fa-dna"></span> Axis 1: Development of Statistical and Machine Learning Methods for Spatial Omics and Single-cell RNA-seq Data</h3>
<p>Our research in spatial omics and single-cell RNA-seq focuses on integrating advanced statistical models and machine learning techniques to uncover spatially resolved gene expression patterns and infer cellular states. We aim to enhance spatial transcriptomic analyses, enabling better disease characterization, biomarker discovery, and precision medicine applications.</p>
<div class="box">
<ul>
<li><strong>CeLEry:</strong> deep learning that leverages spatial transcriptomics to recover cell locations in single-cell RNA-seq data. <em>(Nature Communications, 2023)</em></li>
<li><strong>DiSTect:</strong> a Bayesian model for disease-associated gene discovery and prediction in spatial transcriptomics. <em>(Bioinformatics, 2025)</em></li>
<li><strong>Winnow-KAN:</strong> single-cell RNA-seq location recovery from small gene sets via a Kolmogorov-Arnold network. <em>(BMC Bioinformatics, 2025)</em></li>
<li><strong>SpaTM:</strong> topic models for inferring spatially informed transcriptional programs. <em>(Briefings in Bioinformatics, 2025)</em></li>
<li><strong>DenMark:</strong> a Bayesian hierarchical model for identifying cell-density-correlated genes in spatial transcriptomics. <em>(preprint, bioRxiv 2026)</em></li>
<li><strong>InSTaPath:</strong> integrating spatial transcriptomics and histopathology images via multimodal topic learning. <em>(preprint, bioRxiv 2026)</em></li>
</ul>
</div>
<div class="row">
<div class="lab-members">
<h4>Current Members</h4>
<div class="member">
<img src="images/lab_members/Mingchi.jpg" alt="Mingchi Xu">
<p><strong>Mingchi Xu</strong><br><span class="badge phd">PhD</span> Candidate</p>
</div>
<div class="member">
<img src="images/lab_members/Qicheng.jpg" alt="Qicheng Zhao">
<p><strong>Qicheng Zhao</strong><br><span class="badge phd">PhD</span> Candidate</p>
</div>
<div class="member">
<img src="images/lab_members/Weiyi.jpg" alt="Weiyi Xiao">
<p><strong>Weiyi Xiao</strong><br><span class="badge phd">PhD</span> Candidate</p>
</div>
<div class="member"><img src="images/lab_members/Yuyang.jpg" alt="Yuyang Zhang"><p><strong>Yuyang Zhang</strong><br><span class="badge msc">MSc</span> Candidate</p></div>
<div class="member"><img src="images/lab_members/Yidan.png" alt="Yidan Cui"><p><strong>Yidan Cui</strong><br><span class="badge postdoc">Postdoc</span></p></div>
</div>
<div class="lab-members">
<h4>Alumni</h4>
<div class="member">
<div class="tooltip-card">
<img src="images/lab_members/Anji.jpg" alt="Anji Deng">
<p>
<strong>Anji Deng</strong><br>
<span class="badge msc">MSc</span> Non-thesis
</p>
<span class="tooltip-text"> Next Step: Data Analyst. Faculty of Nursing， University of Alberta</span>
</div>
</div>
<div class="member"><img src="images/lab_members/Qicheng.jpg" alt="Qicheng Zhao"><p><strong>Qicheng Zhao</strong><br><span class="badge msc">MSc</span> Thesis</p></div>
<div class="member"><div class="tooltip-card"><img src="images/lab_members/Kata.png" alt="Kata Vuk"><p><strong>Kata Vuk</strong><br><span class="badge postdoc">Postdoc</span> Visiting</p><span class="tooltip-text">IVADO Visiting Scholar (Opliquepalm). Next Step: Postdoc in Machine Learning, University of Regensburg.</span></div></div>
</div>
</div>
<h3 id="axis2"> <span class="icon solid fa-project-diagram"></span> Axis 2: Methodology for Error-aware Statistical Inference in Modern Settings</h3>
<p>As model-based decision and quantification increasingly impact biomedical research, we focus on developing robust statistical methodologies to ensure reliable inference. Our work addresses measurement error, misclassification, and uncertainty in data analysis to enhance interpretability and accuracy, particlar in machine learning and artificial Intelligence.</p>
<div class="box">
<ul>
<li><strong>Generalized Network Structured Models (GNSM):</strong> network models with mixed responses subject to measurement error and misclassification. <em>(Biometrics, 2023)</em></li>
<li><strong>Generalized SIMEX:</strong> polynomial-extrapolation SIMEX for correcting covariate measurement error. <em>(Statistics in Medicine, 2026)</em></li>
<li><strong>augSIMEX:</strong> analysis of data with mixed measurement error and misclassification in covariates. <em>(Journal of Statistical Computation and Simulation, 2019)</em></li>
<li><strong>Zero-inflated Poisson with measurement error:</strong> Bayesian inference for zero-inflated counts measured with error. <em>(Biometrics, 2023)</em></li>
</ul>
</div>
<div class="row">
<div class="lab-members">
<h4>Current Members</h4>
<div class="member">
<img src="images/lab_members/Mincen.jpg" alt="Mincen Liu">
<p><strong>Mincen Liu</strong><br><span class="badge phd">PhD</span> Candidate</p>
</div>
<div class="member"><img src="images/lab_members/General_male.png" alt="Kejun Fang"><p><strong>Kejun Fang</strong><br><span class="badge undergrad">Undergrad</span></p></div>
<div class="lab-members">
<h4>Alumni</h4>
<div class="member"><div class="tooltip-card"><img src="images/lab_members/CathyShen.jpg" alt="Cathy Shen"><p><strong>Cathy Shen</strong><br><span class="badge msc">MSc</span> Thesis</p><span class="tooltip-text">Next Step: Biostatistician at EVERSANA.</span></div></div>
<div class="member"><div class="tooltip-card"><img src="images/lab_members/Kent_Lu.jpg" alt="Kent Lu"><p><strong>Kent Lu</strong><br><span class="badge msc">MSc</span> Thesis</p><span class="tooltip-text">Next Step: Research Assistant, McGill University.</span></div></div>
<div class="member"><div class="tooltip-card"><img src="images/lab_members/Jou-Chin.jpg" alt="Jou-Chin Wu"><p><strong>Jou-Chin Wu</strong><br><span class="badge phd">PhD</span> Visiting</p><span class="tooltip-text">Next Step: Assistant Professor, National Central University (國立中央大學).</span></div></div>
</div>
</div>
</div>
<h3 id="axis3"> <span class="icon solid fa-heartbeat"></span> Axis 3: Statistics in Applicational and Translational Research</h3>
<p>Our research extends to the application of statistical methods in real-world problems, including public health policy, pandemic modeling, and social data analysis. We integrate machine learning and statistics to derive meaningful insights from diverse data sources.</p>
<div class="box">
<ul>
<li><strong>Sentiment Analysis:</strong> Examining COVID-19 tweets prior to the vaccine rollout to understand public perception and misinformation trends.</li>
<li><strong>Model-based Forecasting:</strong> Predicting Canadian COVID-19 trends using statistical forecasting models to inform public health decision-making.</li>
<li><strong>Effects of Non-Pharmaceutical Interventions:</strong> Estimating the impact of NPIs and mobility patterns on COVID-19 case trajectories in Ontario.</li>
</ul>
</div>
<p style="color: #D3674A; font-weight: normal;">
<span style="font-weight: bold;">To prospective students interested in Axis 3:</span> I currently only serve as a co-supervisor in Axis 3. If you are interested in working with me in this path, please identify a primary supervisor in Epidemiology or Public Health, and I would be happy to serve as a co-supervisor.
</p>
<div class="row">
<div class="lab-members">
<h4>Alumni</h4>
<div class="member">
<div class="tooltip-card">
<img src="images/lab_members/Hani.jpg" alt="Hani Rukh-E-Qamar">
<p>
<strong>Hani Rukh-E-Qamar</strong><br>
<span class="badge msc">MSc</span> Thesis
</p>
<span class="tooltip-text"> Next Step: Medical Student, University of Saskatchewan.</span>
</div>
</div>
<div class="member">
<div class="tooltip-card">
<img src="images/lab_members/Olivia.jpg" alt="Olivia Vaikla">
<p>
<strong>Olivia Vaikla</strong><br>
<span class="badge msc">MSc</span> Thesis
</p>
<span class="tooltip-text"> Next Step: Clinical Research Educator at CANTRAIN.</span>
</div>
</div>
<div class="member">
<div class="tooltip-card">
<img src="images/lab_members/Fio.jpg" alt="Fio Vialard">
<p>
<strong>Fio Vialard</strong><br>
<span class="badge msc">MSc</span> Thesis
</p>
<span class="tooltip-text"> Next Step: PhD Student at Barcelona Institute for Global Health.</span>
</div>
</div>
</div>
</div>
<div class="call-to-action">
<p>Interested in our research? <a href="mailto:qihuang.zhang@mcgill.ca" class="button primary">Email Me</a></p>
</div>
</section>
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<h2>Get In Touch</h2>
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<div class="col-6 col-12-small">
<ul class="actions stacked">
<li><a href="#" class="button primary">Default</a></li>
<li><a href="#" class="button">Default</a></li>
</ul>
</div>
<div class="col-6 col-12-small">
<ul class="actions stacked">
<li><a href="#" class="button primary small">Small</a></li>
<li><a href="#" class="button small">Small</a></li>
</ul>
</div>
<div class="col-6 col-12-small">
<ul class="actions stacked">
<li><a href="#" class="button primary fit">Default</a></li>
<li><a href="#" class="button fit">Default</a></li>
</ul>
</div>
<div class="col-6 col-12-small">
<ul class="actions stacked">
<li><a href="#" class="button primary small fit">Small</a></li>
<li><a href="#" class="button small fit">Small</a></li>
</ul>
</div>
</div>
</section>
<section>
<h4>Table</h4>
<h5>Default</h5>
<div class="table-wrapper">
<table>
<thead>
<tr>
<th>Name</th>
<th>Description</th>
<th>Price</th>
</tr>
</thead>
<tbody>
<tr>
<td>Item One</td>
<td>Ante turpis integer aliquet porttitor.</td>
<td>29.99</td>
</tr>
<tr>
<td>Item Two</td>
<td>Vis ac commodo adipiscing arcu aliquet.</td>
<td>19.99</td>
</tr>
<tr>
<td>Item Three</td>
<td> Morbi faucibus arcu accumsan lorem.</td>
<td>29.99</td>
</tr>
<tr>
<td>Item Four</td>
<td>Vitae integer tempus condimentum.</td>
<td>19.99</td>
</tr>
<tr>
<td>Item Five</td>
<td>Ante turpis integer aliquet porttitor.</td>
<td>29.99</td>
</tr>
</tbody>
<tfoot>
<tr>
<td colspan="2"></td>
<td>100.00</td>
</tr>
</tfoot>
</table>
</div>
<h5>Alternate</h5>
<div class="table-wrapper">
<table class="alt">
<thead>
<tr>
<th>Name</th>
<th>Description</th>
<th>Price</th>
</tr>
</thead>
<tbody>
<tr>
<td>Item One</td>
<td>Ante turpis integer aliquet porttitor.</td>
<td>29.99</td>
</tr>
<tr>
<td>Item Two</td>
<td>Vis ac commodo adipiscing arcu aliquet.</td>
<td>19.99</td>
</tr>
<tr>
<td>Item Three</td>
<td> Morbi faucibus arcu accumsan lorem.</td>
<td>29.99</td>
</tr>
<tr>
<td>Item Four</td>
<td>Vitae integer tempus condimentum.</td>
<td>19.99</td>
</tr>
<tr>
<td>Item Five</td>
<td>Ante turpis integer aliquet porttitor.</td>
<td>29.99</td>
</tr>
</tbody>
<tfoot>
<tr>
<td colspan="2"></td>
<td>100.00</td>
</tr>
</tfoot>
</table>
</div>
</section>
<section>
<h4>Buttons</h4>
<ul class="actions">
<li><a href="#" class="button primary">Primary</a></li>
<li><a href="#" class="button">Default</a></li>
</ul>
<ul class="actions">
<li><a href="#" class="button large">Large</a></li>
<li><a href="#" class="button">Default</a></li>
<li><a href="#" class="button small">Small</a></li>
</ul>
<ul class="actions fit">
<li><a href="#" class="button primary fit">Fit</a></li>
<li><a href="#" class="button fit">Fit</a></li>
</ul>
<ul class="actions fit small">
<li><a href="#" class="button primary fit small">Fit + Small</a></li>
<li><a href="#" class="button fit small">Fit + Small</a></li>
</ul>
<ul class="actions">
<li><a href="#" class="button primary icon solid fa-download">Icon</a></li>
<li><a href="#" class="button icon solid fa-download">Icon</a></li>
</ul>
<ul class="actions">
<li><span class="button primary disabled">Primary</span></li>
<li><span class="button disabled">Default</span></li>
</ul>
</section>
<section>
<h4>Form</h4>
<form method="post" action="#">
<div class="row gtr-uniform gtr-50">
<div class="col-6 col-12-xsmall">
<input type="text" name="demo-name" id="demo-name" value="" placeholder="Name" />
</div>
<div class="col-6 col-12-xsmall">
<input type="email" name="demo-email" id="demo-email" value="" placeholder="Email" />
</div>
<div class="col-12">
<select name="demo-category" id="demo-category">
<option value="">- Category -</option>
<option value="1">Manufacturing</option>
<option value="1">Shipping</option>
<option value="1">Administration</option>
<option value="1">Human Resources</option>
</select>
</div>
<div class="col-4 col-12-small">
<input type="radio" id="demo-priority-low" name="demo-priority" checked>
<label for="demo-priority-low">Low Priority</label>
</div>
<div class="col-4 col-12-small">
<input type="radio" id="demo-priority-normal" name="demo-priority">
<label for="demo-priority-normal">Normal Priority</label>
</div>
<div class="col-4 col-12-small">
<input type="radio" id="demo-priority-high" name="demo-priority">
<label for="demo-priority-high">High Priority</label>
</div>
<div class="col-6 col-12-small">
<input type="checkbox" id="demo-copy" name="demo-copy">
<label for="demo-copy">Email me a copy of this message</label>
</div>
<div class="col-6 col-12-small">
<input type="checkbox" id="demo-human" name="demo-human" checked>
<label for="demo-human">I am a human and not a robot</label>
</div>
<div class="col-12">
<textarea name="demo-message" id="demo-message" placeholder="Enter your message" rows="6"></textarea>
</div>
<div class="col-12">
<ul class="actions">
<li><input type="submit" value="Send Message" class="primary" /></li>
<li><input type="reset" value="Reset" /></li>
</ul>
</div>
</div>
</form>
</section>
<section>
<h4>Image</h4>
<h5>Fit</h5>
<div class="box alt">
<div class="row gtr-50 gtr-uniform">
<div class="col-12"><span class="image fit"><img src="images/fulls/05.jpg" alt="" /></span></div>
<div class="col-4"><span class="image fit"><img src="images/thumbs/01.jpg" alt="" /></span></div>
<div class="col-4"><span class="image fit"><img src="images/thumbs/02.jpg" alt="" /></span></div>
<div class="col-4"><span class="image fit"><img src="images/thumbs/03.jpg" alt="" /></span></div>
<div class="col-4"><span class="image fit"><img src="images/thumbs/04.jpg" alt="" /></span></div>
<div class="col-4"><span class="image fit"><img src="images/thumbs/05.jpg" alt="" /></span></div>
<div class="col-4"><span class="image fit"><img src="images/thumbs/06.jpg" alt="" /></span></div>
<div class="col-4"><span class="image fit"><img src="images/thumbs/03.jpg" alt="" /></span></div>
<div class="col-4"><span class="image fit"><img src="images/thumbs/02.jpg" alt="" /></span></div>
<div class="col-4"><span class="image fit"><img src="images/thumbs/01.jpg" alt="" /></span></div>
</div>
</div>
<h5>Left & Right</h5>
<p><span class="image left"><img src="images/avatar.jpg" alt="" /></span>Fringilla nisl. Donec accumsan interdum nisi, quis tincidunt felis sagittis eget. tempus euismod. Vestibulum ante ipsum primis in faucibus vestibulum. Blandit adipiscing eu felis iaculis volutpat ac adipiscing accumsan eu faucibus. Integer ac pellentesque praesent tincidunt felis sagittis eget. tempus euismod. Vestibulum ante ipsum primis in faucibus vestibulum. Blandit adipiscing eu felis iaculis volutpat ac adipiscing accumsan eu faucibus. Integer ac pellentesque praesent. Donec accumsan interdum nisi, quis tincidunt felis sagittis eget. tempus euismod. Vestibulum ante ipsum primis in faucibus vestibulum. Blandit adipiscing eu felis iaculis volutpat ac adipiscing accumsan eu faucibus. Integer ac pellentesque praesent tincidunt felis sagittis eget. tempus euismod. Vestibulum ante ipsum primis in faucibus vestibulum. Blandit adipiscing eu felis iaculis volutpat ac adipiscing accumsan eu faucibus. Integer ac pellentesque praesent.</p>
<p><span class="image right"><img src="images/avatar.jpg" alt="" /></span>Fringilla nisl. Donec accumsan interdum nisi, quis tincidunt felis sagittis eget. tempus euismod. Vestibulum ante ipsum primis in faucibus vestibulum. Blandit adipiscing eu felis iaculis volutpat ac adipiscing accumsan eu faucibus. Integer ac pellentesque praesent tincidunt felis sagittis eget. tempus euismod. Vestibulum ante ipsum primis in faucibus vestibulum. Blandit adipiscing eu felis iaculis volutpat ac adipiscing accumsan eu faucibus. Integer ac pellentesque praesent. Donec accumsan interdum nisi, quis tincidunt felis sagittis eget. tempus euismod. Vestibulum ante ipsum primis in faucibus vestibulum. Blandit adipiscing eu felis iaculis volutpat ac adipiscing accumsan eu faucibus. Integer ac pellentesque praesent tincidunt felis sagittis eget. tempus euismod. Vestibulum ante ipsum primis in faucibus vestibulum. Blandit adipiscing eu felis iaculis volutpat ac adipiscing accumsan eu faucibus. Integer ac pellentesque praesent.</p>
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